Study: Long-Term CB2R Activation “Might Prevent Neuroinflammation and Oxidative Stress-Associated Sickness Behavior”

Activation of the cannabinoid receptor 2 (CB2R), something done naturally through the consumption of cannabis and cannabinoids, “might prevent neuroinflammation and oxidative stress-associated sickness behavior”, according to a new study.

The study, titled Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice, is being published in the journal Psychopharmacology. It was epublished ahead of print by the U.S. National Institute of Health.

“Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression”, states the study’s abstract. “Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed at evaluating 1-phenylisatin (PI), a CB2R agonist, in sickness behavior.”

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Study: Cannabis Can Attenuate Damage, Improve Memory Retention Following Stroke

Marijuana_Plants-3A new study published by the journal Life Science, and published online by the National Institute of Health, has found that cannabinoid receptor activation – something done naturally by cannabis – can attenuate damage and improve memory retention following a stroke.

“We have recently demonstrated that treatment with a cannabinoid CB2 agonist was protective in a mouse middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury”, begin’s the study’s abstarct. “The present study aimed to determine whether these protective effects of CB2 agonism would extend to a mouse photoinjury model of permanent ischemia and determine associated alterations in cognition and infarct size.

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Cannabinoids May Treat Aggressive Behavior, Finds New Study

A new study budpublished by the journal Psychopharmacology, and conducted by researchers at the Universitat de València in Spain, has found that the body’s cannabinoid receptors play a vital role in the management of social interactions and aggressive behavior, and that administration of a cannabinoid receptor agonist significantly reduces aggression in animal models.

The study’s abstract explains that “This study was designed to examine the role of cannabinoid CB2r in social and aggressive behavior.”

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Cannabis May Improve Outcome of Spinal Cord Injury, Finds Study

Activatiospinaln of the body’s cannabinoid receptors – something done naturally by cannabis – can improve the outcome of spinal cord injury, according to a study published in the most recent issue (Volume 595, May, 2015) of the journal Neuroscience Letters.

For the study, researchers “examined whether treatment with.. a selective synthetic cannabinoid receptor (CB1R) agonist, inhibits MMP [matrix metalloproteinase] and improves functional and histological recovery in a mouse spinal cord compression injury model.” According to the study, MPP iactivity “contributes to glial scar formation that inhibits the repair path after spinal cord injury (SCI)”.

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New Study: Cannabis May Treat Autoimmune Diseases, Prevent Graft Rejection

A newflower study being published in the upcoming issue of the Journal of Neuroimmune Pharmacology, and e-published ahead of print by the National Institute of Health, has found that cannabis may have immunosuppressive and anti-inflammatory properties, which may help treat a variety of conditions such as autoimmune diseases and graft rejection.

According to researchers; “This review examines the effects of cannabinoids on immune function, with a focus on effects on T-cells, as well as on resistance to infection. The paper considers the immune modulating capacity of marijuana, of ∆9-THC extracted from the marijuana plant, and synthetic cannabinoids.”

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