A new study published by the journal Life Science, and published online by the National Institute of Health, has found that cannabinoid receptor activation – something done naturally by cannabis – can attenuate damage and improve memory retention following a stroke.
“We have recently demonstrated that treatment with a cannabinoid CB2 agonist was protective in a mouse middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury”, begin’s the study’s abstarct. “The present study aimed to determine whether these protective effects of CB2 agonism would extend to a mouse photoinjury model of permanent ischemia and determine associated alterations in cognition and infarct size.
For the study, mice received “three injections of the CB2 selective agonist O-1966 or vehicle 1h prior to and 2 and 5days following induction of stroke. Infarct size was assessed at 1, 3, or 7days post-injury and learning and memory effects of injury and O-1966 treatment were assessed on days 6 and 7 using a novel object recognition task and an operant acquisition and retention procedure.”
After conducting the study, researchers concluded that “CB2 activation is protective against cognitive deficits and tissue damage following permanent ischemia”.
The full study, titled A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice, can be found by clicking here.