Study: Marijuana May Have Anti-Obesity Effects
Marijuana may help fight obesity, according to a new study published by the International Journal of Molecular Science.
Noting that “Obesity is an increasing health problem worldwide” and its “related comorbidities imply a high cost for the National Health System and diminish a patient’s life quality”, the study’s abstract states that”Cannabinoid receptors (CB) regulate thermogenesis, food intake and inflammation”.
In this study researchers found that “Stimulation of CB2 limits inflammation and promotes anti-obesity effects by reducing food intake and weight gain.” Stimulation of the CB2 receptors, of course, can occur through the consumption of cannabis and cannabinoids.”
The study’s full abstract can be found below:
Obesity is an increasing health problem worldwide. Its related comorbidities imply a high cost for the National Health System and diminish a patient’s life quality. Adipose tissue is composed of three types of cells. White adipocytes are involved in fat storage and secretion of hormones. Brown adipocytes are involved in thermogenesis and caloric expenditure. Beige adipocytes are transitional adipocytes that in response to various stimuli can turn from white to brown and could be protective against the obesity, enhancing energy expenditure. The conversion of white in beige adipose tissue is a potential new therapeutic target for obesity. Cannabinoid receptors (CB) regulate thermogenesis, food intake and inflammation. CB1 ablation or inhibition helps reducing body weight and food intake. Stimulation of CB2 limits inflammation and promotes anti-obesity effects by reducing food intake and weight gain. Its genetic ablation results in adiposity development. CB receptors are also responsible for transforming white adipose tissue towards beige or brown adipocytes, therefore their modulation can be considered potential anti-obesity target. CB1 principal localization in central nervous system represents an important limit. Stimulation of CB2, principally localized on peripheral cells instead, should facilitate the anti-obesity effects without exerting remarkable psychotropic activity.