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Study Finds CBD has Beneficial Effects in Patients with Schizophrenia

Cannabidiol (CBD) has beneficial effects in patients with schizophrenia, according to a new study published by the American Journal of Psychiatry

“Research in both animals and humans indicates that cannabidiol (CBD) has antipsychotic properties”, begins the study’s abstract. “The authors assessed the safety and effectiveness of CBD in patients with schizophrenia.”

In an exploratory double-blind parallel-group trial, patients with schizophrenia were “randomized in a 1:1 ratio to receive CBD (1000 mg/day; N=43) or placebo (N=45) alongside their existing antipsychotic medication.” Participants were “assessed before and after treatment using the Positive and Negative Syndrome Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS), the Global Assessment of Functioning scale (GAF), and the improvement and severity scales of the Clinical Global Impressions Scale (CGI-I and CGI-S).”

After 6 weeks of treatment, compared with the placebo group, “the CBD group had lower levels of positive psychotic symptoms (PANSS: treatment difference=-1.4, 95% CI=-2.5, -0.2) and were more likely to have been rated as improved (CGI-I: treatment difference=-0.5, 95% CI=-0.8, -0.1) and as not severely unwell (CGI-S: treatment difference=-0.3, 95% CI=-0.5, 0.0) by the treating clinician.” Patients who received CBD “also showed greater improvements that fell short of statistical significance in cognitive performance (BACS: treatment difference=1.31, 95% CI=-0.10, 2.72) and in overall functioning (GAF: treatment difference=3.0, 95% CI=-0.4, 6.4). CBD was well tolerated, and rates of adverse events were similar between the CBD and placebo groups.”

The study concludes by stating that; “These findings suggest that CBD has beneficial effects in patients with schizophrenia. As CBD’s effects do not appear to depend on dopamine receptor antagonism, this agent may represent a new class of treatment for the disorder.”

The full study, published online by the U.S. National Institute of Health, can be found by clicking here.

About Anthony Martinelli

Anthony, co-founder and Editor-in-Chief of TheJointBlog, has worked closely with numerous elected officials who support cannabis law reform, including as the former Campaign Manager for Washington State Representative Dave Upthegrove. He has also been published by multiple media outlets, including the Seattle Times. He can be reached at TheJointBlog@TheJointBlog.com.

1 comment

  1. FredyJohnSmith

    Yes, it’s true as CBD is more effective in the treatment of Schizophrenia as it has antipsychotic properties. Besides fighting life-threatening diseases such as cancer, CBD proves its efficiency in improving the health of the people suffering from Schizophrenia.

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