THC May Treat Spasticity and Pain Associated with Multiple Sclerosis, According to New Research

The oral administration of Δ9-tetrahydrocannabinol (THC) may treat both spasticity and pain associated with multiple sclerosis.

Multiple SclerosisThis is according to a study being published by the journal Clinical Therapeutics, and e-published ahead of print by the U.S. National Institute of Health.

According to the Mayo Clinic, multiple sclerosis (MS) is a “disease in which the immune system eats away at the protective covering of nerves.” The ailment affects around 200,000 people annually and has no cure. Multiple sclerosis causes many different symptoms, including vision loss, pain, fatigue, and impaired coordination.

The aim of the present study was to “evaluate the efficacy of an oral formulation of Δ9-tetrahydrocannabinol (ECP002A) in patients with progressive multiple sclerosis (MS).”

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Study: Cannabis a Potential Treatment Option for Insulin Resistance and Obesity-Related Diabetes

Activation of the cannabinoid 2 receptor – done naturally through the consumption of cannabis and cannabinoids – may be a potential treatment option for insulin resistance and obesity-related diabetes.

 Insulin ResistanceThis is according to new research out of the Institute of Biomedical Engineering at the Chinese Academy of Medical Science; the study was study published in the journal Cellular Physiology and Biochemistry, and epublished by the U.S. National Institute of Health.

“The endocannabinoid signalling (ECS) system has been known to regulate glucose homeostasis”. states the study’s abstract. “Previous studies have suggested that the cannabinoid 2 (CB2) receptor may play a regulatory role on insulin secretion, immune modulation and insulin resistance.”

Given that diabetes and insulin resistance are attributable to elevated inflammatory tone, researchers “investigated the role of CB2 receptor on glucose tolerance and insulin sensitivity in high-fat diet (HFD)/streptozotocin (STZ)-induced mice.”

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Study: Cannabinoids May Treat Chronic Inflammation

Cannabinoids may provide a treatment option for chronic inflammation, according to a new study published in the FASEB Journal, and published online by the U.S. National Institute of Health.

flower-power-2“Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs)”, states the study’s abstract. “As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Their clinical development thus provides a new approach to treatment of diseases characterized by acute and chronic inflammation and fibrosis.”

For the study, a “concise survey of the anti-inflammatory actions of the phytocannabinoids Δ9-tetrahydrocannabinol (THC), cannabidiol, cannabichromene, and cannabinol” is presented.

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Cannabinoids Can Enhance Cartilage Repair, Finds New Study

Cartilage RepairCannabinoids enhance tissue engineering strategies aimed at cartilage repair through a dual function approach, according to a new study published in the journal Pharmaceuticals. The study was published online by the National Institute of Health.

“This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies”, begins the study. “The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on the chondrocyte precursors, mesenchymal stem cells (MSCs).

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Study: THC/CBD in Cannabis Brownies Remain Stable at Least 3 Months at Room Temperature

browniesA new study published in the Journal of Analytical Toxicology, and published online by the National Institute of Health, gives us the clearest answer to date on how long cannabis edibles stay actives after they’ve been made.

“Presented is a method for the preparation and application of THC and CBD containing brownies used as quality control (QC) material for the analysis of marijuana or cannabinoid baked medibles”, states the study’s abstract. “It was determined that the process used to prepare and bake the brownie control material did not degrade the THC or CBD. The brownie matrix was found not to interfere with the analysis of a THC or a CBD.”

Read moreStudy: THC/CBD in Cannabis Brownies Remain Stable at Least 3 Months at Room Temperature

Study: Cannabinoids May Improve Cognitive Performance During Early Tobacco Withdrawal

tobacco withdrawalTobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory, all of which result in an increased relapse risk. According to a new study published in the journal Biological Psychiatry, and published online by the National Institute of Health, cannabinoids may help combat these deficits during early tobacco withdrawal.

For the study, researchers “investigated in mice the role of CB1 cannabinoid receptors (CB1Rs) in memory impairment and spine density changes induced by nicotine withdrawal precipitated by the nicotinic antagonist mecamylamine. Drugs acting on the endocannabinoid system [meant to mimic cannabinoids] and genetically modified mice were used.”

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Study: CBD can Prevent and Induce Cell Death in Cervical Cancer

Cervical CancerA new study published in the journal BMC Complementary and Alternative Medicine, and published online by the National Institute of Health, has found that cannabidiol (CBD) can not only prevent the growth of cervical cancer, it can induce cell death in cervical cancer cell lines.

“In this study we compare the anti-proliferative effects of crude extract of Cannabis sativa and its main compound cannabidiol on different cervical cancer cell lines”, states the study’s abstract. “To achieve our aim, phytochemical screening, MTT assay, cell growth analysis, flow cytometry, morphology analysis, Western blot, caspase 3/7 assay, and ATP measurement assay were conducted.”

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Study: CBD has Longer Treatment Window for Newborn Brain Damage than Other Treatments

Newborn Brain DamageA new study being published in the upcoming issue of the journal CNS & Neurological Disorders – Drug Targets, and published online by the National Institute of Health, has found that cannabidiol (CBD) can treat newborn brain damage, and can do so when administered longer after a dramatic event than other treatment options.

According to the study’s abstract, its purpose was “to test the TTW [therapeutic time window] of the neuroprotective effects of cannabidol (CBD), a non-psychoactive cannabinoid in a model of newborn HI brain damage.”

In doing so, researchers administered CBD to newborn mice with brain damage; it was administered 15 minutes after the induction of brain damage, and then 1, 3, 6, 12, 18 and 24 hours after.

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New Study: Cannabinoids a Promising Tool in Treatment of Breast and Prostate Cancer

Prostate CancerA new study being published in the upcoming issue of the journal Expert Opinion on Investigational Drugs, and published online ahead of print by the U.S. National Institute of Health, has found that cannabinoids may be a promising tool for the treatment of breast and prostate cancer.

According to the study’s abstract; “The aim of this review is to evaluate the promising chemotherapeutic utility of phytocannabinoids, endocannabinoids, and synthetic cannabinoids in breast and prostate cancer.”

In their evaluation, researchers found that; “Cannabinoids, in particular the non-psychoactive CBD, may be promising tools in combination therapy for breast and prostate cancer, due to their direct antitumor effects, their ability to improve the efficacy of conventional antitumor drugs and their usefulness as palliative treatment.”

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Study: Cannabinoids Offer Therapeutic Benefits for Post Traumatic Stress Disorder

Post Traumatic Stress DisorderYet another study has found that cannabinoids may treat or at least greatly benefit those with post traumatic stress disorder (and may prevent it if administered shortly after a traumatic event). The new study was published in the journal Behavioural Pharmacology, and published online by the National Institute of Health.

“There is substantial evidence from studies in humans and animal models for a role of the endocannabinoid system in the control of emotional states”, says the study’s abstract. It states that preliminary studies in humans “suggest that treatment with cannabinoids may decrease PTSD symptoms including sleep quality, frequency of nightmares, and hyperarousal.”

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