University of São Paulo Archives

Study: CBD Induces “Fast and Sustained” Antidepressant-Like Effects

June 6, 2018 by Anthony Martinelli

The findings of a new study published in the journal Molecular Neurobiology “support a promising therapeutic profile for CBD as a new fast-acting antidepressant drug.”

“Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy”, states the study’s researchers, noting that “The development of drugs that addresses these limitations is critical to improving public health.”

Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, “is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans.” However, “its antidepressant properties have not been completely investigated.” Therefore, the aims of this study “were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function.”

Study: Cannabidiol (CBD) May Help Treat Anxiety-Related and Substance Abuse Disorders.

March 10, 2017 by Anthony Martinelli

Cannabidiol (CBD), a cannabis compounds, may be useful in treating anxiety-related disorders as well a substance abuse disorders, according to a new study,

“[C]annabidiol, the main non-psychotomimetic phytocannabinoid found in Cannabis sativa, reduces anxiety”, states the abstract of the study, published by the British Journal of Pharmacology and the U.S. National Institute of Health. “There is also accumulating evidence from animal studies investigating the effects of cannabidiol on fear memory processing indicating that it reduces learned fear in paradigms that are translationally relevant to phobias and post-traumatic stress disorder.”

The abstract continues; “Cannabidiol does so by reducing fear expression acutely and by disrupting fear memory reconsolidation and enhancing fear extinction, both of which can result in a lasting reduction of learned fear. Recent studies have also begun to elucidate the effects of cannabidiol on drug memory expression using paradigms with translational relevance to addiction.

New Study: CBD Prevents and Reverses Antipsychotic-Induced Catalepsy

May 11, 2016May 11, 2016 by Anthony Martinelli

New research published by the U.S. National Institute of Health, and published in-print by the journal Behavioural Brain Research, has found that cannabidiol can attenuate catalepsy induced by haloperidol, and can prevent it if taken prior to the use of haloperidol.

Catalepsy is a trancelike state marked by loss of voluntary motion, sensations and consciousness accompanied by rigidity of the body, and haloperidol is an antipsychotic used to treat certain medical conditions such as Tourette syndrome and bipolar disorder.

“Given that CBD reduces psychotic symptoms without inducing extrapyramidal motor side-effects in animal models and schizophrenia patients, it has been proposed to act as an atypical antipsychotic”, states the study’s abstract. “In addition, CBD reduced catalepsy induced by drugs with distinct pharmacological mechanisms, including the typical antipsychotic haloperidol”

Cannabidiol May Treat Inflammatory Lung Diseases, According to New Study

October 31, 2014October 31, 2014 by Anthony Martinelli

Cannabidiol has a strong anti-inflammatory effect, and can also improve lung function in those with acute lung injury, indicating that it may be a viable treatment option for inflammatory lung diseases, according to a new study published in the journal Immunopharmacology Immunotoxicology.

According to the study; “We have previously shown that the prophylactic treatment with cannabidiol (CBD) reduces inflammation in a model of acute lung injury (ALI). In this work we analyzed the effects of the therapeutic treatment with CBD in mice subjected to the model of lipopolysaccharide (LPS)-induced ALI on pulmonary mechanics and inflammation.”

New Study Finds Cannabinoids May Treat Panic Disorders

August 22, 2014January 21, 2014 by Anthony Martinelli

A new study published in the International Journal of Neuropsychopharmacology, and published online by the National Institute of Health, has found that cannbinoids may treat panic disorders.

“The present study investigated the effects of systemic or intra-dorsolateral periaqueductal gray (dlPAG) administration of CB1 agonists [meant to mimic cannabinoids] on behavioural changes induced in rats by predator (a live cat) exposure, a model of panic responses”, claims the study’s abstract.