Study: THC Inhibits the Growth of Melanoma

THC Molecule.
THC Molecule.

9-tetrahydrocannabinol (THC) inhibits melanoma tumor growth, according to a study published in the most recent issue of the journal Life Science, and published online by the National Institute of Health.

For the study, researchers “examined the effect of THC, which binds to CB receptors (CB1, CB2), on the growth of the mouse melanoma… in vitro and in vivo in wild type (WT) and CB1/CB2-receptor deficient mice (Cnr1/2-/-). Next we evaluated the role of the endogenous cannabinoid system by studying the growth of chemically induced melanomas, fibrosarcoma and papillomas in WT and Cnr1/2-/- mice.”

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Cannabinoids Have Strong Antitumor Capabilities, Says New Study

Cannabinoids have strong antitumor capabilitiesmmjplant according to a new study being published in the upcoming issue of the journal Histology and Histopathology, and e-published ahead of print by the National Institute of Health.

“Cannabinoids are a class of chemical compounds with a wide spectrum of pharmacological effects, mediated by two specific plasma membrane receptors (CB1 and CB2)”, says researchers. “Recently, CB1 and CB2 expression levels have been detected in human tumors, including those of brain.”

According to the study; “Cannabinoids-endocannabinoids exert anti-inflammatory, anti-proliferative, anti-invasive, anti-metastatic and pro-apoptotic effects in different cancer types, both in vitro and in vivo in animal models, after local or systemic administration.”

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Cannabidiol Inhibits Tumor Cells Without Side Effects, Says New Study

A new study published by the National Institute of Health has found that cannabidiol – a cannabis compound – attacks tumor cells, inhibiting them from further growth, by affecting “multiple tumoral features and molecular pathways”.

A 3D model of cannabidiol.
A 3D model of cannabidiol.

“In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and invasiveness in vitro and caused a decrease in the expression of a set of proteins specifically involved in growth, invasion and angiogenesis”, claims the study’s researchers.

“In addition, CBD treatment caused a dose-related down-regulation of ERK and Akt prosurvival signaling pathways in U87-MG and T98G cells and decreased hypoxia inducible factor HIF-1α expression in U87-MG cells.”

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Harvard Study Finds Cannabis Cuts Tumor Growth in Half in Three Weeks

A Harvard study from 2007 which remains the most comprehensive ever released on THC’s potential to combat tumors found that in just three weeks doses of THC were able to cut lung cancer tumor growth in half in mice subjects, and were able to reduce cancer lesions by even more. Harvard study

For the study, Harvard researchers tested THC (delta-9-tetrahydrocannabinol, which is found naturally in cannabis) on cancer cells in labs, and followed that up by studying mice subjects.

The lab demonstration found that doses of THC inhibited growth and spread in the cancer cells; “When the cells are pretreated with THC, they have less EGFR stimulated invasion as measured by various in-vitro assays,” states Anju Preet, PhD, who was one of the researchers for the study.

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