Study: Topical Cannabinoids Reduce Corneal Hyperalgesia and Inflammation

According to a new study published by the journal Cannabis and Cannabinoids Research, and published online by the National Institute of Health, topically-applied cannabinoids are effective in reducing corneal hyperalgesia (defined as a state of nociceptive sensitization caused by exposure to opioids) and inflammation.

“Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization”, begins the study’s abstract. “Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory.” The purpose of this research “was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia.”

Below describes the methods used for this study:

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Study: Topical Marijuana Effective for Managing Pain Associated With Wounds, Can Reduce Opioid Use

Topical marijuana has the potential to improve pain management associated with wounds, according to a study published in the Journal of Pain Management and e-published ahead of print by the U.S. National Institute of Health.

“Pain associated with integumentary wounds is highly prevalent yet it remains an area of significant unmet need within healthcare”, states the study’s abstract. “Currently, systemically administered opioids are the mainstay of treatment. However, recent publications are casting opioids in a negative light given their high side effect profile, inhibition of wound healing, and association with accidental overdose, incidents that are frequently fatal.” Thus, “novel analgesic strategies for wound-related pain need to be investigated”.

Researchers state that the ideal methods of pain relief for wound patients are “modalities that are topical, lack systemic side effects, non-invasive, self-administered, and display rapid onset of analgesia”, and; “Extracts derived from the cannabis plant have been applied to wounds for thousands of years”. The discovery of the “human endocannabinoid system and its dominant presence throughout the integumentary system provides a valid and logical scientific platform to consider the use of topical cannabinoids for wounds.”

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