Study: THCA has “Potent Neuroprotective Activity”

According to a new study, Δ9-tetrahydrocannabinol acid (THCA) has potent neuroprotective activity which may help treat Huntington´s Disease and other neurodegenerative and neuroinflammatory diseases.

thca
(Photo: Leafly)

“Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing, and storage”, states the abstract of the study, published by the British Journal of Pharmacology and the U.S. National Institute of Health. “While the biological effects of decarboxylated cannabinoids such as Δ9 -tetrahydrocannabinol (Δ9 -THC) have been extensively investigated, the bioactivity of Δ9 -THCA is largely unknown, despite its occurrence in different Cannabis preparations.” The aim of this study “was to determine whether Δ9 -THCA modulates the PPARγ pathway and has neuroprotective activity”.

For the study; “The effects of six phytocannabinoids on PPARγ binding and transcriptional activity were investigated.” In doing so, researchers found that;

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Study: THCA May Treat Neurodegenerative and Neuroinflammatory Diseases

According to a new study, tetrahydrocannabinolic acid (THCA), a compound found in cannabis, may be useful in treating neurodegenerative and neuroinflammatory diseases.

“While the biological effects of decarboxylated cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) have been extensively investigated, the bioactivity of Δ9-THCA is largely unknown, despite its occurrence in different Cannabis preparations”, states the study, published in the British Journal of Pharmacology. “The aim of this study was to determine whether Δ9-THCA modulates the PPARγ pathway and has neuroprotective activity”.

For the study; “The effects of six phytocannabinoids on PPARγ binding and transcriptional activity were investigated. The effect of Δ9-THCA on mitochondrial biogenesis and PGC-1α expression was investigated in N2a cells.” The neuroprotective effect “was analysed in STHdhQ111/Q111 cells expressing a mutated form of the huntingtin protein, and in N2a cells infected with an adenovirus carrying human huntingtin containing 94 polyQ repeats (mHtt-q94).” In vivo neuroprotective activity of Δ9-THCA “was investigated in mice intoxicated with the mitochondrial toxin 3-nitropropionic acid (3-NP).”

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Virginia Legislature Passes Bill Allowing Use and Distribution of CBD and THC-A Oil

Virginia’s full legislature has given approval to legislation allowing for the production and distribution of medical oil made from cannabidiol (CBD) or THC-A (tetrahydrocannabinol acid).

Under current Virginia law, oil made from CBD or THCA (both compounds found in cannabis) is legal to possess and use for medical purposes, but only for those with intractable epilepsy. There also isn’t a safe, legal means for patients to access the oil.

The newly-approved measure would greatly expand the list of conditions that makes someone eligible to use these medicines to include HIV/AIDS, cancer, Crohn’s disease, multiple sclerosis and several others. The proposal also allows pharmacies to manufacture and distribute the medicines to qualified patients (those with a qualifying condition who receive a recommendation from a physician and register with the state).

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Virginia House of Representatives Unanimously Approves Bill to Legalize Cannabis Oil for Medical Use

Two containers filled with cannabis oil.
Two containers filled with cannabis oil.

Virginia’s House of Representatives has given unanimous approval to a proposal to legalize the medical use of high-CBD and high-THCA cannabis oil for those with epilepsy.

A similar measure was approved 37 to 1 in the Senate last week. Once the two chambers reconcile the technical differences of the measures, which is expected to happen this week, it will head to Governor McAuliffe for consideration. McAuliffe will have the option of signing the measure into law, letting it become law without his signature, or vetoing it. However, given there was such strong consensus in the Legislature, there would be more than enough votes to override a potential veto.

Read moreVirginia House of Representatives Unanimously Approves Bill to Legalize Cannabis Oil for Medical Use

Bill to Allow the Medical Use of Cannabis Oil Passes Virginia Senate with 37 to 1 Vote

Withoil a 37 to 1 vote, Senate Bill 1235 was passed today by Virginia’s Senate. The proposal would allow for the use of of high-CBD and high-THCA cannabis oil for those with epilepsy who receive a recommendation from a physician.

Specifically, Senate Bill 1235 would allow those with epilepsy who receive a recommendation from a physician to possess and use cannabis oil that has at least 15% cannabidiol (CBD) or 15% THCA (tetrahydrocannabinol acid), and no more than 5% THC. The measure doesn’t, however, authorize dispensaries to produce or distribute the medicine, so patients unfortunately will be left to either importing it, producing it themselves illegally or purchasing it illegally.

Read moreBill to Allow the Medical Use of Cannabis Oil Passes Virginia Senate with 37 to 1 Vote