Study: Long-Term CB2R Activation “Might Prevent Neuroinflammation and Oxidative Stress-Associated Sickness Behavior”

Activation of the cannabinoid receptor 2 (CB2R), something done naturally through the consumption of cannabis and cannabinoids, “might prevent neuroinflammation and oxidative stress-associated sickness behavior”, according to a new study.

The study, titled Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice, is being published in the journal Psychopharmacology. It was epublished ahead of print by the U.S. National Institute of Health.

“Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression”, states the study’s abstract. “Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed at evaluating 1-phenylisatin (PI), a CB2R agonist, in sickness behavior.”

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Study: Cannabigerol May Treat Neuroinflammation and Oxidative Stress

According to a new study published by the International Journal of Molecular Sciences, the cannabis compound cannabigerol “may be a potential treatment against neuroinflammation and oxidative stress.”

“Inflammation and oxidative stress play main roles in neurodegeneration”, states the study’s abstract. “Interestingly, different natural compounds may be able to exert neuroprotective actions against inflammation and oxidative stress, protecting from neuronal cell loss. Among these natural sources, Cannabissativa represents a reservoir of compounds exerting beneficial properties, including cannabigerol (CBG), whose antioxidant properties have already been demonstrated in macrophages.”

With this in mind, researches “aimed to evaluate the ability of CBG to protect motor neurons against the toxicity induced from the medium of LPS-stimulated RAW 264.7 macrophages.”

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