Study: THC May Treat Diabetes-Induced Cardiovascular Disease

According to a new study published by the journal BioMed Research International, tetrahydrocannabinol (THC) may be “a potential new target for the treatment of diabetes-induced cardiovascular disease.”

“The aim of this study was to determine if chronic, low-dose administration of a nonspecific cannabinoid receptor agonist could provide cardioprotective effects in a model of type I diabetes mellitus”, states the study’s abstract. “Diabetes was induced in eight-week-old male Wistar-Kyoto rats.. Following the induction of diabetes, Δ9-tetrahydrocannabinol was administered via intraperitoneal injection (0.15 mg kg-1 day-1) for an eight-week period until the animals reached sixteen weeks of age.”

Upon completion of the treatment regime, “assessments of vascular reactivity and left ventricular function and electrophysiology were made, as were serum markers of oxidative stress and lipid peroxidation.” According to researchers, “Δ9-Tetrahydrocannabinol administration to diabetic animals significantly reduced blood glucose concentrations and attenuated pathological changes in serum markers of oxidative stress and lipid peroxidation. Positive changes to biochemical indices in diabetic animals conferred improvements in myocardial and vascular function. This study demonstrates that chronic, low-dose administration of Δ9-tetrahydrocannabinol can elicit antihyperglycaemic and antioxidant effects in diabetic animals, leading to improvements in end organ function of the cardiovascular system.”

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Study: Cannabis a Potential Treatment Option for Insulin Resistance and Obesity-Related Diabetes

Activation of the cannabinoid 2 receptor – done naturally through the consumption of cannabis and cannabinoids – may be a potential treatment option for insulin resistance and obesity-related diabetes.

 Insulin ResistanceThis is according to new research out of the Institute of Biomedical Engineering at the Chinese Academy of Medical Science; the study was study published in the journal Cellular Physiology and Biochemistry, and epublished by the U.S. National Institute of Health.

“The endocannabinoid signalling (ECS) system has been known to regulate glucose homeostasis”. states the study’s abstract. “Previous studies have suggested that the cannabinoid 2 (CB2) receptor may play a regulatory role on insulin secretion, immune modulation and insulin resistance.”

Given that diabetes and insulin resistance are attributable to elevated inflammatory tone, researchers “investigated the role of CB2 receptor on glucose tolerance and insulin sensitivity in high-fat diet (HFD)/streptozotocin (STZ)-induced mice.”

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