Study: Topical Cannabinoids Reduce Corneal Hyperalgesia and Inflammation

According to a new study published by the journal Cannabis and Cannabinoids Research, and published online by the National Institute of Health, topically-applied cannabinoids are effective in reducing corneal hyperalgesia (defined as a state of nociceptive sensitization caused by exposure to opioids) and inflammation.

“Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization”, begins the study’s abstract. “Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory.” The purpose of this research “was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia.”

Below describes the methods used for this study:

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