Study: Cannabinoids May Help Treat Gut Inflammation

There’s “abundant preclinical literature demonstrating the anti-inflammatory effects of cannabinoid drugs in inflammation of the gut”, according to a new study published by the journal Inflammatory Bowel Disease.

For the study, researchers “systematically reviewed publications on the benefit of drugs targeting the endo-cannabinoid system in intestinal inflammation.” They “collated studies examining outcomes for meta-analysis from EMBASE, MEDLINE and Pubmed until March 2017. Quality was assessed according to mSTAIR and SRYCLE score.”

For the study, “51 publications examining the effect of cannabinoid compounds on murine colitis and 2 clinical studies were identified. Twenty-four compounds were assessed across 71 endpoints. Cannabidiol, a phytocannabinoid, was the most investigated drug.”

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Marijuana and Chili Peppers Calm Gut’s Immune System, May Treat Type 1 Diabetes and Colitis

Marijuana and chili peppers may help treat diabetes and colitis by calming the gut, according to new research conducted at the University of Connecticut.

Chili peppers and marijuana may not have much in common, but when eaten, both interact with the same receptor in our stomachs. This is according to a study conducted by University of Connecticut (UConn) researchers, published in the April 24 issue of the journal Proceedings of the National Academy of Sciences. The data could lead to new therapies for diabetes and colitis, and opens up intriguing questions about the relationship between the immune system, the gut and the brain, says researchers.

“Touch a chili pepper to your mouth and you feel heat”, states a UConn press release. “And biochemically, you aren’t wrong. The capsaicin chemical in the pepper binds to a receptor that triggers a nerve that fires off to your brain: hot! Those same receptors are found throughout the gastrointestinal tract, for reasons that have been mysterious.”

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Study: Cannabinoids Play a Protective Role Against Colitis

Cannabinoids can have anti-inflammatory effects and can play a protective role in patients with colitis; colitis is in an inflammatory reaction in the colon which is often infection or autoimmune.

ColitisThis is according to a study published in the World Journal of Gastroenterology, and published online by the U.S. National Institute of Health.

According to researchers, the study’s aim was to; “investigate the anti-inflammatory effect and the possible mechanisms of an agonist of cannabinoid (CB) receptors, WIN55-212-2 (WIN55) [meant to mimic the effects of natural cannabinoids], in mice with experimental colitis, so as to supply experimental evidence for its clinical use in future.

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Study: Cannabis May Protect Against Colitis

A new study publishedbrightleaf in the journal ACS Medicinal Chemistry Letters has found that activation of the cannabinoid receptors – something done naturally by cannabis – can protect against colitis, which is an inflammatory reaction in the colon that is often autoimmune or infectious.

According to the study; “The CB2 cannabinoid receptor has been implicated in the regulation of intestinal inflammation”. With this in mind, researchers “developed constrained analogues” that were specifically designed to target the body’s cannabinoid receptors.

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