Study: CBDA and THC Have Anti-Inflammatory and Anti-Hyperalgesia Effects

Both cannabidiolic acid (CBDA) and tetrahydrocannabinol (THC) show  anti-inflammatory and anti-hyperalgesia effects on acute inflammation, according to a new study published by the journal Psychopharmacology, and epublished ahead of print by the National Institute of Health.

“The present study evaluates the anti-inflammatory and anti-hyperalgesia effects of CBD’s potent acidic precursor, cannabidiolic acid (CBDA), in a rodent model of carrageenan-induced acute inflammation in the rat hind paw, when administered systemically (intraperitoneal, i.p.) or orally before and/or after carrageenan”, begins the study’s abstract. “In addition, we assess the effects of oral administration of THC or CBDA, their mechanism of action, and the efficacy of combined ineffective doses of THC and CBDA in this model. Finally, we compare the efficacy of CBD and CBDA.”

Researchers found that “CBDA given i.p. 60 min prior to carrageenan (but not 60 min after carrageenan) produced dose-dependent anti-hyperalgesia and anti-inflammatory effects. In addition, THC or CBDA given by oral gavage 60 min prior to carrageenan produced anti-hyperalgesia effects, and THC reduced inflammation.”

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Study: Cannabidiolic Acid (CBDA) Inhibits Highly Aggressive Breast Cancer

Aggressive Breast CancerCannabidiolic acid (CBDA), a little-known compound found in cannabis, can inhibit the migration of highly aggressive breast cancer, according to a study published by the Journal of Natural Medicines and published online by the National Institute of Health.

“The biological activities of CBDA have been attracting increasing attention”, states the study’s researchers, who “identified CBDA as an inhibitor of the migration of MDA-MB-231 cells, a widely used human breast cancer cell line in cancer biology, due to its highly aggressive nature.”

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Study: THC and CBDA Effective in Treating and Preventing Nausea, Stimulating Appetite

cannabiscuresnauseaAdministration of extremely small amounts of THC (tetrahydrocannabinol) and CBDA (cannabidiolic acid) – both cannabis compounds – is effective in treating and preventing nausea, and stimulating appetite, in those going through chemotherapy, a new study has found. The study was published in the journal Psychopharmacology, and published online by the National Institute of Health.

“The objective of this study was to determine the effect of combining subthreshold oral doses of Δ9-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models of conditioned gaping”, states the study’s abstract.

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