Study: Cannabinoids May Treat Newborn Brain Injury Caused by Germinal Matrix Hemorrhage

An important new study published by the National Institute of Health has found that activation of the endocannabinoid system – something donemedcannabis naturally by cannabinoids – can attenuate newborn brain injury caused by germinal matrix hemorrhages, which is one of the most common and devastating cerebrovascular events that affect premature infants.

For the study, researchers investigated the effects of a cannabinoid receptor 2 (CB2R) agonist – meant to mimic the effect of cannabinoids – on young rats with germinal matrix hemorrhages (GMH).

“We demonstrated that activation of CB2R played a key role in attenuating brain edema, neuronal degeneration, microglial accumulation and the phosphorylated extracellular signal-regulated kinase (p-ERK) protein level 24 h following GMH”, says researchers.

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Study: THC Inhibits the Growth of Melanoma

THC Molecule.
THC Molecule.

9-tetrahydrocannabinol (THC) inhibits melanoma tumor growth, according to a study published in the most recent issue of the journal Life Science, and published online by the National Institute of Health.

For the study, researchers “examined the effect of THC, which binds to CB receptors (CB1, CB2), on the growth of the mouse melanoma… in vitro and in vivo in wild type (WT) and CB1/CB2-receptor deficient mice (Cnr1/2-/-). Next we evaluated the role of the endogenous cannabinoid system by studying the growth of chemically induced melanomas, fibrosarcoma and papillomas in WT and Cnr1/2-/- mice.”

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New Cannabis and Cannabinoid Research Journal Launching in the Fall

Cannabis cannabiscuresnauseaand Cannabinoid Research, a new peer-reviewed, open access journal, will launch this fall as the world’s first journal dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and the biochemical mechanisms of endocannabinoids.

“Launching in fall 2015, the Journal will be the premier open source for authoritative cannabis and cannabinoid research, discussion, and debate” states a recent press release from Mary Ann Liebert, Inc., the publishing company behind the new journal, which will be published “under the Creative Commons Attribution 4.0 (CC BY) license to ensure broad dissemination and participation.”

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Study Finds Cannabinoids Show ‘Great Promise’ as Treatment for Nausea

Cannabinoids showcannabis “great promise” as a treatment option for nausea, according to a new study published in the journal Clinical Pharmacology & Therapeutics, and published online by the National Institute of Health.

“The sensation of nausea is one of the most debilitating human experiences”, according to the study’s researchers. “Current anti-emetic therapies are effective in reducing vomiting, but are less effective in reducing acute and delayed nausea and are completely ineffective in reducing anticipatory nausea.”

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Cannabinoids May Treat Prostate Cancer That’s Nonresponsive to Common Therapies

Cannabinoids may cannabinoidsprovide a treatment option for prostate cancer that has become nonresponsive to common therapy, according to a study published in the February issue of the journal Oncology Reports, and published online this week by the National Institute of Health.

According to researchers; “In the early stages, prostate cancer is androgen‑ dependent; therefore, medical castration has shown significant results during the initial stages of this pathology. Despite this early effect, advanced prostate cancer is resilient to such treatment.”

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Study: Cannabinoids Can Cause Cancer Cells to Burst

A new study published last week by the journal Biochemical Pharmacology, and published online by the National Institute of Health, has found budplantthat cannabinoids can increase a cancer cell’s susceptibility to cytolysis, which occurs when a cell bursts due to an imbalance.

“Cannabinoids have been shown to promote the expression of the intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells as part of their anti-invasive and antimetastatic action”, says Burkhard Hinz, the study’s lead author. “Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, the present study addressed the impact of cannabinoid-induced ICAM-1 on cancer cell adhesion to lymphokine-activated killer (LAK) cells and LAK cell-mediated cytotoxicity.”

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THC Can Protect Against Inflammation-Induced Cognitive Damage, According to New Study

Low doses of THC (tetrahydrocannabinol) can protect the brain from neuroinflammation-induced cognitive damage andthcannabis “might be used as an effective drug for the treatment of neuroinflammatory conditions, including neurodegenerative diseases”, according to a new study published in the Journal of Neuroscience Research.

“In our previous studies, we found that a single ultralow dose of tetrahydrocannabinol (THC; 0.002 mg/kg, three to four orders of magnitude lower than the conventional doses) protects the brain from different insults that cause cognitive deficits”, says the study’s researchers. “Because various insults may trigger a neuroinflammatory response that leads to secondary damage to the brain, the current study tested whether this extremely low dose of THC could protect the brain from inflammation-induced cognitive deficits.”

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Study: Targeting Cannabinoid Receptors May Provide Treatment Option for Alcoholism

A study published this month in the journal Pharmacology Biochemistry and Behavior has found that targeting the body’s cannabinoid receptors mayalcohol provide a viable treatment option for alcoholism.

For the study, a compound (BCP) meant to mimic the effects of cannabis “was used to investigate the role of the CB2 receptors in mediating alcohol intake and ethanol-induced conditioned place preference (EtOH-CPP) and sensitivity in mice. The effect of BCP on alcohol intake was evaluated using the standard two-bottle choice drinking method. The mice were presented with increasing EtOH concentrations and its consumption was measured daily. Consumption of saccharin and quinine solutions was measured following the EtOH preference tests. Finally, the effect of BCP on alcohol reward and sensitivity was tested using an unbiased EtOH-CPP and loss of righting-reflex (LORR) procedures, respectively.”

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Neuropsychopharmacology Journal Publishes Study Showing Cannabinoids Can Treat PTSD

A new study e-published ahead of print by Neuropsychopharmacology, the official publication of the American College of mmjbuddingNeuropsychopharmacology, has determined that cannabinoids can help treat, or even prevent, the effects of PTSD.

Scientists from the Department of Psychology of the University of Haifa in Israel examined rat models suffering from shock-induced PTSD (post-traumatic stress disorder). The rats were each given an injection of either a cannabinoid receptor agonist (a substance that mimics the effects of cannabis) or a control placebo 2 hours after the shock.

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Cannabis May Treat Neurodegeneration According to New Study

A new study published in the British Journal of Pharmacology has found that cannabis may treat neurodegenerative diseases such as Alzheimer’s disease.braincannabis

“In an increasingly ageing population, the incidence of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are rising”, according to the study. “While the aetiologies of these disorders are different, a number of common mechanisms that underlie their neurodegenerative components have been elucidated; namely neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced trophic support. Current therapies focus on treatment of the symptoms and attempt to delay the progression of these diseases but there is currently no cure.” It continues; “Modulation of the endogenous cannabinoid system is emerging as a potentially viable option in the treatment of neurodegeneration. Endocannabinoid signalling has been found to be altered in many neurodegenerative disorders.”

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