The recent use of cannabis is associated with improved outcomes in patients hospitalized with intracerebral hemorrhaging (ICH aka bleeding in the brain), according to data published online ahead of print in the journal Cerebrovascular Diseases.
An international team of investigators from Argentina, Italy, the Netherlands, and the United States evaluated demographic trends and patient outcomes in a cohort of 725 subjects with spontaneous ICH. Researchers reported that cannabis-positive subjects possessed “milder ICH presentation” upon hospitalization and presented “less disability” at discharge as compared to similarly matched patients who tested negative for cannabinoids.
An important new study published by the National Institute of Health has found that activation of the endocannabinoid system – something done naturally by cannabinoids – can attenuate newborn brain injury caused by germinal matrix hemorrhages, which is one of the most common and devastating cerebrovascular events that affect premature infants.
For the study, researchers investigated the effects of a cannabinoid receptor 2 (CB2R) agonist – meant to mimic the effect of cannabinoids – on young rats with germinal matrix hemorrhages (GMH).
“We demonstrated that activation of CB2R played a key role in attenuating brain edema, neuronal degeneration, microglial accumulation and the phosphorylated extracellular signal-regulated kinase (p-ERK) protein level 24 h following GMH”, says researchers.
A new study being published in next month’s issue of the journal Biochemical Society Transactions, and published online early by the National Institute of Health, has found that the brain’s endocannabinoid system – which is activated through cannabis use – has neuroprotective and immunomodulatory capabilities, and may lead to the growth of stem cells.
“Activation of cannabinoid receptors suppresses chronic inflammatory responses through the attenuation of pro-inflammatory mediators”, states the study’s abstract. “Moreover, the endocannabinoid system directs cell fate specification of NSCs (neural stem cells) in the CNS (central nervous sytem)”.
A new study, published in the August edition of Neuropharmacology, has found that cannabis may serve as a neuroprotectant.
Researchers from the University Hospital Puerta de Hierro Majadahonda, in Madrid, Spain, examined the effect of CBD when applied to a hypoxic-ischemic (HI) brain injury model (most common in instances such as cardiac arrest, when blood flow stops or slows, and oxygen can’t effectively reach the brain). The scientists interrupted carotid blood flow and reduced oxygen intake levels to 10% in animal subjects for 30 minutes. The damage of the HI injury was immense: