Cannabis May Treat Rheumatoid Arthritis, According to Study

By Rachel Lutz,

A treatment thatSynapse targets the CB2 cannabinoid receptor [example; cannabis] may be an effective treatment for rheumatoid arthritis and synovitis, according to research published in BMC Musculoskeletal Disorders.

A collaborative team of researchers from the United Kingdom investigated cannabinoid receptor isoform CB2 as a target for treatment for rheumatoid arthritis while reviewing current treatments available to patients. The researchers noted synovitis is a central component of rheumatoid arthritis while also contributing to osteoarthritis. While pain symptoms can be treated in these diseases with medications like NSAIDs or paracetamol, control of rheumatic pain is particularly difficult. Breakout medications the researchers identified were sprifermin (human recombinant FGF-18) and tanezumab (anti-NFG monoclonal antibody).

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Study: Cannabis May Treat Rheumatoid Arthritis

An example of rheumatoid arthritis. [WebMD]
An example of rheumatoid arthritis. [WebMD]
A new study being published in the upcoming issue of the journal BMC Musculoskeletal Disorders, and e-published ahead of print by the National Institute of health, has found that a cannabinoid receptor agonist can successfully help against some of the primary symptoms of rheumatoid arthritis (RA), indicating that cannabis, which is a natural agonist to the body’s cannabinoid receptors, may provide a treatment option for the condition.

For the study, mice with RA were injected with JWH133, a selective CB2 [cannabinoid receptor type 2] agonist, and it was found that it “reduced the arthritis score, inflammatory cell infiltration, bone destruction, and anti-CII IgG1 production.”

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