New findings “strongly suggest” that cannabidiol (CBD) may be useful in the treatment of alcohol use disorders.
The study, published by the journal Addiction Biology, “evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse” in mice.” The effects of “CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated.”
Researchers used the two-bottle choice paradigm to assess the effects of CBD (30, 60 and 120 mg/kg/day, i.p) on ethanol intake and preference. In addition, “an oral ethanol self-administration experiment was carried out to evaluate the effects of CBD [a single s.c. administration of a microparticle formulation providing CBD continuous controlled release (30 mg/kg/day)] on the reinforcement and motivation for ethanol. The effects of CBD (60 and 120 mg/kg/day, i.p.) on ethanol-induced relapse were also evaluated.”