Study: CBD Induces “Fast and Sustained” Antidepressant-Like Effects

The findings of a new study published in the journal Molecular Neurobiology “support a promising therapeutic profile for CBD as a new fast-acting antidepressant drug.”

“Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy”, states the study’s researchers, noting that “The development of drugs that addresses these limitations is critical to improving public health.”

Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, “is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans.” However, “its antidepressant properties have not been completely investigated.” Therefore, the aims of this study “were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function.”

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