A new study published recently by the International Journal of Clinical and Experimental Medicine has found that cannabidiol (CBD), a compound found in cannabis, can prevent seizures in those with chronic epilepsy, and can decreased neuronal damage caused by seizures. The study was also published by the U.S. National Institute of Health.
“The study was designed to investigate the effect of various concentrations of cannabidiol (CBD) in rats with chronic epilepsy”, states the study’s abstract. “The chronic epilepsy rat model was prepared by intraperitoneally injecting pentylenetetrazole to the rats pre-treated with CBD (10, 20 and 50 mg/kg) for 28 consecutive days.”
After examining the rat models, researchers found that a “significant decrease in the daily average grade of epileptic seizures on treatment with CBD (50 mg/kg). The neuronal loss and astrocyte hyperplasia in the hippocampal area were also decreased. CBD treatment did not affect the expression of iNOS in the hippocampus; however, the expression of NR1 was decreased significantly.”
The study concludes; “Thus, CBD administration inhibited the effect of pentylenetetrazole in rats, decreased the astrocytic hyperplasia, decreased neuronal damage in the hippocampus caused by seizures and selectively reduced the expression of the NR1 subunit of NMDA. Therefore, CBD exhibits an anticonvulsive effect in the rats with chronic epilepsy.”
The full study can be found by clicking here.