Bacterial translocation, which is the migration of bacteria from the intestinal lumen to mesenteric lymph nodes (according to Medscape), is increased in those with cirrhosis, and can lead to spontaneous bacterial peritonitis (SBP). SBP is a condition which symptoms include fevers, chills and vomiting. According to a new study published by the Journal of Hepatology, cannabinoid receptor agonists – something which cannabis naturally is – may treat bacterial translocation and other “relevant abnormalities”.
For the study, researchers at the National Yang-Ming University School of Medicine, and Chang Gung University’s Graduate Institute of Traditional Chinese Medicine (both in Taiwan), gave cannabinoid receptor agonists to “thioacetamide (TAA)- and common bile duct ligation (BDL)-cirrhotic rats with ascites for 2-weeks and various measurement were performed.”
After performing the measurements and studying the results, researchers found that; “CB2R agonist have the potential to treat BT [bacterial translocation] and various relevant abnormalities through the inhibition of systemic/intestinal oxidative stress, inflammatory cytokines and TNFα releases in cirrhosis. Overall, chronic CB2R agonist treatment affects multiple approach mechanisms, and the direct effect on hyperdynamic circulation is only minor.”
The study can be found by clicking here.