Study: Cannabinoids May Be An Effective Adjunct Treatment for Pancreatic Cancer

Cannabinoids “may be an effective adjunct for the treatment of pancreatic cancer”, according to a new study.

The study, titled Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer, was published by the Journal of Pancreatic Cancer, and has been epublished by the National Institute of Health.

“Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes”, begins the study’s abstract. “The aim of this review is to determine the potentially utility of cannabinoids in the treatment of pancreatic cancer.”

For the study, “A literature review focused on the biological effects of cannabinoids in cancer treatment, with a focus on pancreatic cancer, was conducted. In vitro and in vivo studies that investigated the effects of cannabinoids in pancreatic cancer were identified and potential mechanisms of action were assessed.”

According to researchers, “Cannabinol receptors have been identified in pancreatic cancer with several studies showing in vitro antiproliferative and proapoptotic effects. The main active substances found in cannabis plants are cannabidiol (CBD) and tetrahydrocannabinol (THC).” There effects are “predominately mediated through, but not limited to cannabinoid receptor-1, cannabinoid receptor-2, and G-protein-coupled receptor 55 pathways.” In vitro studies consistently demonstrated tumor growth-inhibiting effects with CBD, THC, and synthetic derivatives.

“Synergistic treatment effects have been shown in two studies with the combination of CBD/synthetic cannabinoid receptor ligands and chemotherapy in xenograft and genetically modified spontaneous pancreatic cancer models”, notes the study. “There are, however, no clinical studies to date showing treatment benefits in patients with pancreatic cancer.”

The study concludes by stating that “Cannabinoids may be an effective adjunct for the treatment of pancreatic cancer. Data on the anticancer effectiveness of various cannabinoid formulations, treatment dosing, precise mode of action, and clinical studies are lacking.”

The full study, published by researchers at the University of Melbourne in Australia, can be found by clicking here.

According to a study of nearly 3,000 people published last year, it was found that cannabis appears to be a safe, effective and well tolerated palliative treatment for cancer.

The study was published in the European Journal of Internal Medicine, and published online by the U.S. National Institute of Health. The study of 902 patients concludes by stating that “Cannabis as a palliative treatment for cancer patients seems to be well tolerated, effective and safe option to help patients cope with the malignancy related symptoms.”

That study and its abstract can be found by clicking here

A study released in September found cannabis to be useful treating a different type of cancer. The study concludes; “This combinatory therapy approach provides new opportunities to treat TNBC [triple negative breast cancer] with high efficacy. In addition, this study provides new evidence on the therapeutic potential of CB2R agonists for cancer.”

A separate study released the same month found that cannabinoids may provide a potential treatment option for prostate cancer. The study, published by the journal The Prostate, concludes by stating that “The following study provides evidence supporting the use of WIN as a novel therapeutic for prostate cancer.” For the full study click here.

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