Study: Cannabidiol Protects Against Cocaine Toxicity

cbdA new study published by the journal Mediators of Inflammation, and published online by the National Institute of Health, has found that cannabidiol, a compound found in cannabis, can protect against cocaine toxicity, minimizing inflammatory injury caused by use of the drug.

“Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality”, begins the study’s abstract. “The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity.”

Researchers found that “URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury. Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure.”

The study concludes; “These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.

The full study, which is titled Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine, can be found by clicking here.

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1 comment

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