Regular Marijuana Use Associated With Increased Testosterone, Finds Study

Regular Marijuana Use Associated With Increased Testosterone, Finds Study

According to a new study, men who report having consumed marijuana in the past year possess elevated levels of testosterone as compared to non-users. The study, titled The effect of tetrahydrocannabinol on testosterone among men in the United States: Results from the National Health and Nutrition Examination Survey, was published in the World Journal of Urology.

For the study researchers from the University of Chicago, the University of Miami, and John Hopkins University in Baltimore assessed the relationship between past-year marijuana use and testosterone levels in a cohort of self-reported cannabis consumers.

“[M]en who reported smoking THC in the last year on average had a higher T (testosterone level) compared to those who did not report using THC”, states the study. Those who use marijuana at least two or three times per month possessed the greatest differences compared to non-users, says researchers.

The study concludes by stating: “[This] analysis of a nationally representative cohort suggests that there is a dose-dependent effect of THC on T levels. … Future prospective work using specific doses of THC and studies elucidating the mechanism of the association is required to corroborate these findings.”

The full abstract of the study can be found below:

PURPOSE:

To determine the association between tetrahydrocannabinol (THC) use and testosterone (T) levels among men in the United States.

METHODS:

Using the National Health and Nutrition Examination Survey (NHANES) data from the years 2011-2016, we identified all men 18 years and older who answered the substance use questionnaire and underwent laboratory testing for T. Regular THC users were defined as those who use THC at least one time per month, every month for at least 1 year. Multivariable linear regressions controlling for confounders were then used to determine the relationship between THC use and T levels.

RESULTS:

Among the 5146 men who met inclusion, 3027 endorsed using THC at least once in their life (ever-user). Nearly half of the THC ever-users (49.3%) were considered regular THC users. Multivariate analysis controlling for age, comorbidities, tobacco use, alcohol use, body mass index (BMI), exercise level, and race revealed a small but statistically significant increase in T among regular THC users at any measured level of use, compared to non-regular THC users (non-users). This increase was characterized by an inverse U-shaped trend with Regular THC users using two-three times per month demonstrating the greatest increase in T (+ 66.77 ng/dL) over non-users.

CONCLUSION:

THC use is associated with small increases in testosterone. This increase in T appears to decline as THC use increases, but nevertheless, T is still higher with any amount of regular use when compared to T in non-users. Prospective work is needed to validate the observed increase and to better elucidate the mechanism of impact THC use has on T levels.

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