Cannabinoids May Treat Alzheimer’s Disease, Finds New Study

Cannabinoids may provide an effective treatment option for Alzheimer’s disease, according to new research published in the European Journal of Pharmacology, and e-published ahead of print by the U.S. National Institute of Health.

“Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neuroinflammation, extensive deposits of amyloid-β aggregates, and loss of memory and cognitive abilities”, states the study’s abstract. “The brains of patients with AD [Alzheimer’s disease] show increased expression of cannabinoid receptor type 2 (CB2) receptors and glial markers. CB2 receptors act as a negative feedback regulator; when activated by a CB2 agonist, they can help limit the extent of the neuroinflammatory response and the subsequent development of neuronal damage in the central nervous system.”

In a double transgenic APP/PS1 mice model of AD, researchers evaluated the effect of a CB2 agonist (meant to mimic the effects of cannabinoids) on several neuropathological conditions of AD including “amyloid deposition, inflammatory reaction, Sox2 (sex-determining region Y-box 2) expression, and spatial memory.”

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New Hampshire Senate Committee Votes to Establish Commission to Study Marijuana Legalization

Nevada’s Senate Judiciary Committee has voted to establish a commission designed to study the legalization of marijuana.

House Bill 215 will now move towards a vote by the full Senate. Given it has already been passed by the full House of Representatives, passage in the Senate would send it to Governor Chris Sununu for consideration.

The 22-person commission would be tasked with examining “the possible impacts of changing state policy to treat marijuana in a manner similar to the way the state deals with alcohol and shall study the legalization, regulation, and taxation of marijuana including the specific issues related to growing, selling, taxing, limiting use, advertising, promoting, and otherwise regulating marijuana and marijuana-infused edible products.”

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Nevada Legislature Approves Measure to Legalize Hemp

Legislation that would legalize hemp throughout Nevada has been given approval by the state’s full legislature.

Senate Bill 396 received unanimous approval in the Senate late last month, and it has now been passed by the full Assembly with a 34 to 5 vote. With it being approved through both chambers, it will now be sent to Governor Brian Sandoval for consideration. Sandoval has the option of signing it into law, allowing it to become law without his signature, or vetoing it (if he does veto it the legislature could override it with a 2/3rds majority).

Senate Bill 396 would expand upon a current law that allows hemp to be grown in the state for research purposes by creating “a separate program for the growth and cultivation of industrial hemp and produce agricultural hemp seed in this State”; this would allow hemp to be grown for commercial – and not exclusively research – purposes.

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Maine Legislature Passes Bill to Fund Implementation of Marijuana Legalization

Maine’s full legislature has passed a bill to fund the implementation of the successful 2016 marijuana legalization initiative and change the agency that will regulate marijuana for adult use.

The Senate on Thursday passed LD 243 unanimously “under the hammer,” without debate or a roll call vote, sending it to Gov. Paul LePage for final approval. The House passed it “under the hammer” on Wednesday.

LD 243 would transfer the authority to oversee adult-use marijuana from the Department of Agriculture, Conservation and Forestry to the Bureau of Alcoholic Beverages and Lottery Operations within the Department of Administrative and Financial Services (DAFS). The Bureau would be responsible for licensing adult-use marijuana businesses and creating and enforcing regulations. LD 243 also allocates $200,000 to the Joint Select Committee on Marijuana Legalization Implementation and $1.4 million to DAFS to implement Question 1.

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Vermont Governor Vetoes Marijuana Legalization Bill

Vermont Governor Phil Scott has vetoed a bill to legalize marijuana, saying it’s possible a compromise could be reached during the summer.

Senate Bill 22 would have legalized the possession of up to an ounce of marijuana, and the personal cultivation of up to two mature plants (four immature), for those 21 and older. The measure was approved by the Senate 20 to 9, and by the House of Representatives 79 to 66. The proposal is the first legalization bill to ever be approved by a state legislature (the eight states with legal cannabis did so through the initiative process).

“We are disappointed by the governor’s decision to veto this widely supported legislation, but we are very encouraged by the governor’s offer to work with legislators to pass a legalization bill during the summer veto session”, says Matt Simon, New England political director for the Marijuana Policy Project. “Most Vermonters want to end marijuana prohibition, and it is critical that the legislature respond by passing a revised legalization bill this summer. Marijuana is less harmful than alcohol, and there is no good reason to continue treating responsible adult consumers like criminals.”

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Cannabis Use Doesn’t Harm, May Improve Eyesight, Finds Study

Cannabis use doesn’t harm eyesight quality, according to a new study published by the journal Optometry and Vision Science.

According to researchers; “The aim of this study was to investigate if heavy marijuana smoking is associated with a poor quality of eyesight compared with light/no use of marijuana.”

To conduct the study, “The National Longitudinal Survey of Youths (NLSY79), a nationally representative sample of 12,686 young men and women surveyed in 1979 to 2010 was used”. The quality of eyesight of 1304 heavy marijuana users was compared with 1304 respondents with light or no marijuana use. The t test, multivariate and weighted logistic regression were used in the data analysis.

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Cannabinoids May Treat Oxidative Stress-Related Neurodegenerative Disorders, Says New Study

Cannabinoids have therapeutic potential in oxidative stress-related acute or chronic neurodegenerative disorders from stroke, multiple sclerosis and traumatic brain injury to Alzheimer`s and Parkinson`s diseases, according to a new study.

The study, conducted by researchers at the National Institute of Health (NIH) and Rutgers New Jersey Medical School, is being published in the journal Antioxidants & Redox Signaling, and has been e-published ahead of print by NIH’s

According to the study’s abstract:

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Tomorrow Vermont Governor Will Sign or Veto Bill to Legalize Marijuana

Vermont Governor Phil Scott says that tomorrow he will either sign into law, or veto a measure to legalize marijuana.

Governor Phil Scott has until tomorrow, May 24th to either sign or veto a legislature-approved measure (Senate Bill 22) to legalize marijuana. If Scott doesn’t act, the bill will become law without his signature, something he says he won’t allow.

Governor Scott says that he has yet to decide whether or not he will sign or veto the measure, which would legalize the possession and personal cultivation of marijuana for those 21 and older. The bill would allow possession of up to an ounce, and personal cultivation of up to two mature and four immature plants. A commission would be established to study the possible legalization of cannabis retail outlets.

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Nevada Hemp Bill Passed by Assembly Committee, Already Passed Full Senate

A bill to legalize hemp in Nevada has been approved by a key Assembly committee; it’s already passed the full Senate.

The Assembly Committee on Natural Resources, Agriculture, and Mining gave approval Friday to Senate Bill 396, sending it towards a vote by the full Assembly. Given the measure has already been passed by the Senate (with a unanimous 20 to 0 vote), passage in the Assembly would send it to Governor Brian Sandoval for consideration.

Under current Nevada law, it’s legal for an institution of higher education or the state’s Department of Agriculture to grow or cultivate industrial hemp for purposes of research conducted under an agricultural pilot program or for other agricultural or academic research. Senate Bill 396 creates “a separate program for the growth and cultivation of industrial hemp and produce agricultural hemp seed in this State”, allowing hemp to be grown for commercial purposes.

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Study: Infusion of Cannabinoids in Spinal Canal Effective at Blocking Pain

Activation of the body’s cannabinoid receptors through spinal infusion is effective at blocking pain, according to a new study published by the journal Regional Anesthesia and Pain Medicine.

“Cannabinoid receptors (CB1R/CB2R) are known to play important roles in pain transmission”, begins the study’s abstract. “In this study, we investigated the effects of continuous intrathecal infusion of CB1/2R agonists in the L5/6 spinal nerve ligation pain model.” Intrathecal infusion is a form of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid. A CB1/2R agonist is something that activates the cananbinoid receptors, which is done naturally by cannabis and cannabinoids.

Under isoflurane anesthesia, “rats received nerve ligation and intrathecal catheter connected to an infusion pump”. After surgery, saline and three forms of cannabinoid receptor agonists was given intrathecally for 7 days. The mechanical and thermal sensitivities of rat hindpaw were determined by von Frey hair and radiant heat tests. The expression of CB1/2R and protein levels of CB1/2R, Iba1, glial fibrillary acidic protein, and tumor necrosis factor α were examined by immunofluorescence study and Western blotting.

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