New Study Finds Cannabis Oral Spray Dramatically Improves Peripheral Neuropathic Pain

marijuana card

New Study Finds Cannabis Oral Spray Dramatically Improves Peripheral Neuropathic Pain

A new study just released out of the U.K., and recently published in the Journal of Neurology, has examined the efficacy of the THC/CBD oromucosal spray Sativex on peripheral neuropathic pain (PNP). sativex-anwendung-ms

The peripheral nervous system connects nerves from the spinal cord and brain to the rest of the body; the pain associated with peripheral neuropathy, or the damaging of these nerves, can be very difficult to treat.

Over the course of 38 weeks, researchers examined 380 patients from all over the world (U.S., U.K., Canada, Czech Republic, Romania and Belgium) suffering from peripheral neuropathic pain associated with diabetes (peripheral neuropathy is the most common side effect of diabetes) or allodynia (allodynia is pain resulting from things that normally shouldn’t cause pain, such as a light touch, mild skin temperatures or normal movement of joints and muscles).

Patients received a THC/CBD oral spray and were asked to report the severity of their neuropathic pain on a scale of 0-10. Overall, the patient group reported a significantly decreased pain rating, beginning with a mean score of 6.9 before using the spray and dropping down to a mean score of 4.2 after use. At least half of all patients reported a 30% improvement in pain at all time points (reviews were conducted at 2, 14, 26 and 38 weeks into the study), and the amount of patients who reported an improvement of 30% or more continued to increase over time, up to 9 months.

Delta Extrax

Researchers also found improvements in all secondary outcomes of using the oral spray that were examined, including patients’ sleep quality scores, subject global impression of change and EQ-5D questionnaire scores (standardized measurements of health improvement).

The study concludes that, “THC/CBD spray was well tolerated for the study duration and patients did not seek to increase their dose with time, with no new safety concerns arising from long-term use. In this previously difficult to manage patient population, THC/CBD spray was beneficial for the majority of patients with PNP associated with diabetes or allodynia.”

– TheJointBlog


  • Mario Saucedo
    October 17, 2014

    This is what I talking abut , the cure of all diseases of the world is on the rainforest herbs and healthy eating .

  • Elizabeth Lowery
    October 17, 2014

    I would like to order some too see if it helps. Is it legal How can I try it?

  • Kim Miller
    October 17, 2014

    This is a wonderful example of how marijuana can be used without involving the smoking it. Peripheral neuropathy is an extremely painful disorder and without the use of opioid drugs, life can become unbearable. This is a fantastic development in treating the pain associated with this disorder.

    If only it were legal, like so many of the extremely dangerous drugs used currently to treat peripheral neuropathy such as Lyrica, and Neurontin. Horrible side effects abound and mostly ineffective if you survive the side effects.

    LEGALIZE for the sake of Peripheral Neuropathy sufferers, PLEASE!

    See Link for the following page:
    “Opposition to Kentucky HB 1-Reform HB 217 aka “Pill Mill Bill”

  • deb
    October 17, 2014

    Does anyone know of any research of this treatment for cluster migraines that can last sometimes for weeks?

  • barbara
    October 17, 2014

    Would love to be able to get some of this my husband and I both suffer from health conditions this would help with.Can any one tell me where we can get this

  • kicker
    October 18, 2014

    As this was not a double blind study it should be taken with a pinch of salt. It could be due to the placebo effect, 30% seems about right. A proper double blind study would include a control group with a spray not containing the THC, neither the person using it nor the researcher dealing with them would know which was which until after the trial, thus eliminating the placebo effect.

  • Anonymous
    April 7, 2015


Post a Comment