New Study: Cannabis Can Slow, Cure Alzheimer’s Disease

A new study conducted by researchers at the Roskamp Institute in Florida, and published in the journal Molecular and Cellular Neuroscience,MMMA LEAF AND SYMBOL_full has found that cannabis can slow the effects of Alzheimer’s Disease, and may in fact be able to halt it entirely.

According to Corbin Bachmeier, Ph.D – who’s the lead researcher of the study – Alzheimer’s Disease is “the result of impaired Aβ [Amyloid-β protein] clearance from the brain”. According to this study, cannabis can solve this problem, making it a potential treatment.

Here’s the study’s abstract:

Emerging evidence suggests beta-amyloid (Aβ) deposition in the Alzheimer’s disease (AD) brain is the result of impaired clearance, due in part to diminished Aβ transport across the blood–brain barrier (BBB). Recently, modulation of the cannabinoid system was shown to reduce Aβ brain levels and improve cognitive behavior in AD animal models. The purpose of the current studies was to investigate the role of the cannabinoid system in the clearance of Aβ across the BBB. Using in vitro and in vivo models of BBB clearance, Aβ transit across the BBB was examined in the presence of cannabinoid receptor agonists and inhibitors. In addition, expression levels of the Aβ transport protein, lipoprotein receptor-related protein1 (LRP1), were determined in the brain and plasma of mice following cannabinoid treatment. Cannabinoid receptor agonism or inhibition of endocannabinoid-degrading enzymes significantly enhanced Aβ clearance across the BBB (2-fold). Moreover, cannabinoid receptor inhibition negated the stimulatory influence of cannabinoid treatment on Aβ BBB clearance. Additionally, LRP1 levels in the brain and plasma were elevated following cannabinoid treatment (1.5-fold), providing rationale for the observed increase in Aβ transit from the brain to the periphery. The current studies demonstrate, for the first time, a role for the cannabinoid system in the transit of Aβ across the BBB. These findings provide insight into the mechanism by which cannabinoid treatment reduces Aβ burden in the AD brain and offer additional evidence on the utility of this pathway as a treatment for AD.

This research validates past studies (including some presented earlier this year, as well as a 2006 study), though is the first to actually explain why cannabis can be beneficial to the disease.

TheJointBlog

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    • Patricia Vaughn on January 12, 2018 at 6:45 pm
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    I come from a huge family history of Alzheimer’s including my Mom, my maternal Aunt, my Grandmother, Great Aunt….When I was diagnosed, they gave me the standard meds for Alzheimer’s and they did nothing for me. I started doing research and decided that there was enough evidence that Cannabis may help that I decided to try it. That was probably about 5 years ago and I am still in the Mild Cognitive Impairment stage. I am still doing everything I have always done, including driving (just took a drivers test and aced it), taking care of my own finances and paying my own bills. Shopping and cooking all meals for my Husband and I, take care of our large house, cleaning, shopping, laundry etc. I am by no means cured, but I have not been progressing at the rate that I remember my other family members did. I think that part of it is my mindset. When my Mother was diagnosed, my Father never let her do anything after that. So she just sat down and let it happen. I refused to allow that to happen to me. I started researching and decided that it didn’t look like there was going to be a cure for a while, so I read about ways I might slow it down. I became a Vegan and started exercising so much I have destroyed my knees and need replacement on at least one. Because there is no cure at this point does not mean that we can’t slow it down. I will not kid you, it is not easy, changing your lifestyle, but the way I look at it is that it is better than what will happen if I don’t try. My Doctor has been quite impressed and I am hoping to keep it at bay until they find better treatments than what they have so far.

    • Maddy on October 7, 2014 at 4:08 pm
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    I would like to know if you need the THC or only the thc free cannaboids to treat Alzheimer’s.

      • Pat on January 26, 2018 at 8:16 pm
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      From what I have read, it is the THC that is good for the dementia (Google it). I come from a large family history of Alzheimer’s and was diagnosed at least about 4 or 5 years ago with mild cognitive impairment. I started doing research and kept coming back to articles about Cannabis helping Alzheimer’s. I do not want to spend my days high (it defeats the purpose), so I take CBD (the non psychoactive part of cannabis), two times during the day and THC at bedtime. So far that has worked very well for me. I have been doing this for at least several years and my Neurologist has been very happy with how slowly I am progressing. I do not take any of the recommended meds for dementia because I tried them early on and felt they did nothing for me. I also became a Vegan as soon as I was diagnosed and started exercising so much, that I have destroyed my knees and need at least one of them replaced. I don’t want to have surgery until I really have to for fear it will worsen the dementia. Basically, most people don’t eat really healthy and don’t exercise enough, so we need to “clean up our act” 😀 While it has not cured me, it has certainly not hurt me and like I mentioned above, my Dr. has been very pleased. Good luck to you. Please feel free to reply if you have any other questions. Just DON”T GIVE IN to this disease. We may not be able to cure it, but I have been able to slow it down and right now that will have to be enough.

    • Roxane on August 31, 2014 at 7:42 pm
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    My husband who is 64 was showing very significant signs of cognitive impairment. Since both his parents have alzheimers it was very alarming. I read everything I could find about possible supplements for improving memory and started him on a number of them ( coconut oil, alpha gpc, huperzine a, ginko baloba, bacopa, etc.).
    Recently I read about cannabis being more effective than the pharmaceuticals currently used for alzheimers, so I decided to try him on a very low non psychoactive dose daily.
    I have been putting a very weak dose (not enough to be psychoactive) of homemade cannaoil in his coffee every night for the last two weeks and I have noticed he is no longer repeating himself and that his memory is significantly improved.
    Perhaps there is no correlation and he is just having a good spell, but I am hopeful…

      • R. Boisvert on September 11, 2015 at 9:14 am
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      Roxane,

      I see your post was in August, 2014. Have you noticed and more improvement since Aug. 2014

      R. Boisvert

    • Vicks kounelis on July 31, 2014 at 6:24 am
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    Like to know if I can get the cannabis oil to cure bone cancer stage 4 . I live in sydney australia.

  1. we carry it

    • KH Medical on May 27, 2014 at 1:59 pm
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    Is there anyone that needs help locating this miracle oil?

      • james on May 30, 2014 at 8:12 am
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      Yes please

    1. Both my Mother in law and Father in law have cancer. I have spoken to both of them about cannabis oil, and they both were receptive to the ideal. My father in law is in really bad shape, and I would like so much to help them both. I love them and want them to heal from this disease, and I know cannabis oil will work. Problem is, I don’t know how to go about attaining it for them. Thank you.

    • KH Medical on May 27, 2014 at 1:58 pm
    • Reply

    If there is anyone within the State of California who needs help locating these miracle oils – please do not hesitate to contact me at – kingharvestapothecary@gmail.com – Prop 215 Compliant Only

    We are King Harvest Apothecary – A not for profit compassionate care provider that specializes in Cannabis based Critical Illness medicines … We offer a full arsenal of Cannabis Oils, solvent free RSO preparations, Edible Food grade cooking oils, Tinctures, CBD Wellness Therapies, Infused Alcohols, Infused Organic Sugars and raw cooking products. In addition to this we offer complimentary healing modalities that extend far beyond the boundaries of just “Cannabis Science” – After all this is about wellness … this is about personal freedom and this is about being of “service”.

    The adventure began by simply trying to save my own life …from a seizure disorder and it has organically grown from there. So let me be quite clear … I would absolutely not be alive today if not for this medicine. And so it began … One by one people have come to us with different debilitating conditions ~ and we have grown into a collective. We are now a “Town Hall Style Health and Wellness Community” dedicated to creating some of the most effective Cannabis based cures on the planet. If that is something that you find inspiring – then please join us and read on …

    ~ We believe in both the medicine and the miracle –
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    • D. Oberhaus on February 28, 2014 at 7:35 am
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    Now is the time, before I forget my children. Please allow us to opportunity to help ourselves by legalizing marijuana NOW.

    • Anonymous on July 26, 2013 at 12:15 am
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    my granmother has been suffering with alzheimers for 8 years now and has nearly completely lost her mind, if this was available a few years ago and the government would pull thier finger out, maybe she would still remember who i was

    • Cindy Howell on July 17, 2013 at 9:21 pm
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    At the age of 61 my husband has moderate to late Alzheimer’s . If this, or anything else, would help him, and the studies have been done…please put it out there for us to try!

      • Sally Jones on November 9, 2013 at 12:08 am
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      My husband is in the same shape as yours and there is no treatment at all. We would be happy to try anything at all if he could get even a little better.

      • Johnny on November 21, 2013 at 4:35 am
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      My mother who is 83 has Alzheimers its the hardest thing to look after her and slowly watch her waste away. She has wild mood swings from super happy to violent if the weed can help set it free and stop all our suffering

      • Anonymous on September 16, 2017 at 11:53 am
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      Cindy, I am 67 years old and come from a large family history of Alzheimer’s. A couple of years ago I started to feel like things were changing in my brain. Because of the family history, I was sure that I was next in line for the “family” disease. The standard drugs for Alzheimer’s/dementia did nothing for me. I started doing a lot of research and what I came up with was that marijuana is a very can be very effective. I live in a medical marijuana state and decided that I had nothing to lose. I had used marijuana recreationally some years ago, so I decided to give it a try. It helps a great deal. I am not so sure about it curing me, because I have not seen that yet, but it helps me live a more “normal” life. I would recommend it to anyone with memory issues. I hope this helps. Good luck to both of you.

    • GENNELL GRAHAM on July 10, 2013 at 6:08 pm
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    MARIJUANA SHOULD BE LEGALIZED. THERE ARE MORE PLUSSES THAN MINUSES.

      • toasty on July 30, 2013 at 12:44 pm
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      Not for the Big Pharma companies.

    • GENNELL GRAHAM on July 10, 2013 at 6:05 pm
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    LEGALIZE POT.

    • RonM on July 10, 2013 at 10:24 am
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    With millions and millions of aging citizens becoming afflicted with Alzheimer’s disease and other forms of dementia it has never been more important to loosen restrictions, decriminalize, and legalize marijuana.

    Please sign the petition below we only need 9 more signatures for the petition to be posted on the Whitehouse petition website.

    To all who cherish freedom,

    Our nation watches and the resolve builds to end Marijuana Prohibition in the United States of America.

    We have to keep the pressure on our government to decriminalize marijuana.

    Please sign the new whitehouse petition,

    http://wh.gov/lOmFK

    Decriminalize marijuana, and pardon all marijuana convictions. Over 100,000,000 U.S. Citizens have used marijuana.

    With over 500,000 marijuana arrests costing over $13 billion annually, and with more than half of U.S. Citizens favoring legalization the time is here to end marijuana prohibition.

    Marijuana prohibition is very costly to society, wasting billions of dollars and billions of hours in law enforcement, justice system and penal system time, it also destroys families and personal lives and futures.

    The effects of marijuana both physically and socially are less harmful than alcohol or tobacco, and adults should be entitled to make the decision whether or not to consume marijuana.

    It’s time to finally put an end to the criminalization of marijuana, This would not only allow our government to save billions of dollars, but could be a source of income and bring in billions of dollars in revenue.

    Please help to spread the word on any social media you can, we need this petition to go VIRAL!

    Thank you,

    RonM

    • Howard on July 10, 2013 at 8:57 am
    • Reply

    There’s a terrific irony here. Ronald Reagan suffered from Alzheimer’s disease (likely during part of his presidency). He possible could have benefited from cannabis to alleviate his condition. Yet he uttered this famous quote;

    ‘I now have absolute proof that smoking even one marijuana cigarette is equal in brain damage to being on Bikini Island during an H-Bomb blast.’

    Hmm.

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