Study: Washington Teens Not Using More Marijuana Following Legalization

The legalization of marijuana in Washington State is not associated with an increase in marijuana use by most teens, according to a study published in The Journal of Adolescent Health.

For the study researchers from Washington State University, the University of Massachusetts, and the Colorado School of Public Health assessed trends in teen marijuana use and employment in the years immediately prior to and immediately following the enactment of retail marijuana sales (2010 to 2016), reports NORML in a news release.

The study found that “marijuana use decreased significantly among working and non-working 8th and 10th graders.” Marijuana use similarly declined among 12th graders who were not employed, while among 12th graders who were employed more than eleven hours per week marijuana use actually increased over the study period, though just slightly. The study’s authors acknowledged that this latter finding was not unexpected because “the workplace may expose adolescents to peer or adult coworkers’ potentially unhealthy behaviors, including substance use.” Authors further acknowledged that working youth were also more likely to have reported using cannabis prior to the passage of legalization.

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Study: CBD May be Effective in the Treatment of Painful Diabetic Neuropathy

According to a new study being published by the journal Brain Research, and epublished online by the National Institute of Health,  cannabidiol (CBD) ” may be effective in the treatment of painful diabetic neuropathy “.

“Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective”, states the study’s abstract. “Cannabidiol (CBD) has shown promising results in painful conditions.” With this in mind, researchers “aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms.”

For the study, “Wistar adult male diabetic rats were treated acutely or sub-chronically (for 14 days) with CBD (0.1, 0.3 or 3 mg/Kg, intraperitoneal; i.p.) and had their mechanical threshold assessed using the electronic Von Frey. ” Acute treatment with CBD (at doses of 0.3 and 3 mg/Kg) “exerted a significant anti-allodynic effect, which is not associated with locomotor impairment. “The antinociceptive effect of CBD (3 mg/Kg) was not altered by the pre-treatment with CB1 or CB2 receptor antagonists (AM251 and AM630; respectively; both at a dose of 1 mg/kg, i.p.) nor by glycine receptor antagonist (strychnine hydrochloride, 10 μg/rat, intrathecal, i.t.).”

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Regular Marijuana Use Associated With Reduced BMI, Says Study

Marijuana use over time is inversely related to obesity, according to a new study published in the International Journal of Epidemiology.

For the study researchers assessed the relationship between cannabis use and body mass index (BMI) over time in a nationally representative sample of 33,000 subjects.

Investigators reported that cannabis-using subgroups exhibited “appreciably attenuated BMI gain” over the trial period as compared to non-users and quitters, “with the largest attenuation seen in the ‘persistent use’ group.”

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Report: Over 200,000 Full-Time Jobs Created by State-Legal Marijuana Businesses

Marijuana businesses that are legal under their state’s law hired 64,000 new employees in 2018, and now employs over 200,000 full-time workers, according to data compiled by Whitney Economics and Leafly.com.

The report, entitled Cannabis Jobs Count, identifies some 211,000 full-time jobs in the legal cannabis sector. This total increases to 296,000 jobs when ancillary employers are also included.

By comparison, 112,000 Americans are estimated to currently work in the textile industry, while only about 52,000 people are employed by the coal mining industry.

“[T]he legal cannabis industry remains a substantial and unrecognized engine of grassroots job creation,” authors concluded. “In fact, cannabis job growth is proceeding at double digit rates in many states despite being overtaxed locally and heavily penalized at the federal level.”

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Study: Cannabinoids May Be An Effective Adjunct Treatment for Pancreatic Cancer

Cannabinoids “may be an effective adjunct for the treatment of pancreatic cancer”, according to a new study.

The study, titled Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer, was published by the Journal of Pancreatic Cancer, and has been epublished by the National Institute of Health.

“Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes”, begins the study’s abstract. “The aim of this review is to determine the potentially utility of cannabinoids in the treatment of pancreatic cancer.”

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Study: Marijuana Consumption Linked to Increased Sperm Count

Men who have consumed marijuana have higher sperm counts than those who have never used it, according to a new study published in the February 6th issue of the journal Human Reproduction.

This longitudinal study “included 662 subfertile men enrolled at the Massachusetts General Hospital Fertility Center between 2000 and 2017.” The men “provided a total of 1143 semen samples; 317 men also provided blood samples in which we measured reproductive hormones.”

Researchers found that “Men who had ever smoked marijuana had higher sperm concentration and count and lower serum FSH [follicle stimulating hormone] concentrations than men who had never smoked marijuana; no differences were observed between current and past marijuana smokers.”

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Study: CBD May Help Treat Alcohol Use Disorder

Cannabidiol shows promise as a potential treatment option for alcohol use disorder, according to a new study published by the journal Alcoholism: Clinical and Experimental Research, and epublished by the U.S. National Institute of Health.

“There is substantial interest in the therapeutic potential of cannabidiol (CBD), a non-psychoactive cannabinoid found in plants of the genus Cannabis”, begins the abstract of the study. “The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a candidate pharmacotherapy for alcohol use disorder (AUD).”

Using a comprehensive search strategy, “303 unique potential articles were identified and 12 ultimately met criteria for inclusion (8 using rodent models, 3 using healthy adult volunteers, and 1 using cell culture).” In both rodent and cell culture models, “CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus.” In rodent models, “CBD was found to attenuate alcohol-induced hepatotoxicity, specifically, alcohol-induced steatosis.”

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Study: Long-Term CB2R Activation “Might Prevent Neuroinflammation and Oxidative Stress-Associated Sickness Behavior”

Activation of the cannabinoid receptor 2 (CB2R), something done naturally through the consumption of cannabis and cannabinoids, “might prevent neuroinflammation and oxidative stress-associated sickness behavior”, according to a new study.

The study, titled Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice, is being published in the journal Psychopharmacology. It was epublished ahead of print by the U.S. National Institute of Health.

“Cannabinoid receptor 2 (CB2R) signaling in the brain is associated with the pathophysiology of depression”, states the study’s abstract. “Sickness behavior, characterized by lessened mobility, social interaction, and depressive behavior, is linked with neuroinflammation, oxidative stress, and immune system. The present study was aimed at evaluating 1-phenylisatin (PI), a CB2R agonist, in sickness behavior.”

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Study Finds High-CBD Cannabis Oil is Safe And Effective for Autistic Patients

The administration of cannabis extracts is effective and well-tolerated in patients diagnosed with autism spectrum disorders (ASD), according to a new study published in the journal Scientific Reports and published online by the National Institute of Health.

The aim of the study, which included 188 participants,  was to “characterize the epidemiology of ASD patients receiving medical cannabis treatment and to describe its safety and efficacy.” To do this researchers examined the daily administration of high-CBD cannabis oil. which consisted of 30% CBD and 1.5% THC.

Among the patients who used the cannabis oil for at least six months, over 90% reported some level of symptomatic improvement; this included reductions in seizures, rage attacks and restlessness. In addition, roughly a third of reported a reduction in other medications.

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Study: CBD May Enhance Treatment Efficiacy in Glioblastoma Multiforme (Brain Tumor)

CBD may “act as an adjunct to enhance treatment efficacy” in glioblastoma multiforme, which is “the most common and aggressive form of primary malignant brain tumor in adults”, according to a study published by the journal Translational Oncology.

“Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults, with poor prognosis”, states the study’s abstract. “Extracellular vesicles (EVs) are key-mediators for cellular communication through transfer of proteins and genetic material. Cancers, such as GBM, use EV release for drug-efflux, pro-oncogenic signaling, invasion and immunosuppression; thus the modulation of EV release and cargo is of considerable clinical relevance.”

As EV-inhibitors have been shown to increase sensitivity of cancer cells to chemotherapy, “and we recently showed that cannabidiol (CBD) is such an EV-modulator”, researchers “investigated whether CBD affects EV profile in GBM cells in the presence and absence of temozolomide (TMZ).” Compared to controls, “CBD-treated cells released EVs containing lower levels of pro-oncogenic miR21 and increased levels of anti-oncogenic miR126; these effects were greater than with TMZ alone. In addition, prohibitin (PHB), a multifunctional protein with mitochondrial protective properties and chemoresistant functions, was reduced in GBM cells following 1 h CBD treatment.”

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