Cannabis May Prevent and Treat Non-Alcohol Related Fatty Liver Disease

Cannabis may cannabisplanttreat as well as prevent non-alcohol related fatty liver disease, according to a study published this month in the Journal of Hepatology, and published online by the National Institute of Health.

According to researchers; “Obesity and associated metabolic syndrome have quickly become a pandemic and a major detriment to human health globally. The presence of non-alcoholic fatty liver disease (NAFLD; hepatosteatosis) in obesity has been linked to the worsening of the metabolic syndrome, including the development of insulin resistance and cardiovascular disease.”

They continue; “Currently, there are few options to treat NAFLD, including life style changes and insulin sensitizers. Recent evidence suggests that the cannabinoids Δ9-tetrahydrocannabivarin (THCV) and cannabidiol (CBD) improve insulin sensitivity; we aimed at studying their effects on lipid levels.”

After examining the effects THCV and CBD on lipid levels using “a variety of in vitro and in vivo systems, with special emphasis on models of hepatosteatosis”, it was found that “THCV and CBD directly reduce accumulated lipid levels in vitro in a hepatosteatosis model and adipocytes. Nuclear Magnetic Resonance- (NMR) based metabolomics confirmed these results and further identified specific metabolic changes in THCV and CBD-treated hepatocytes.”

Researchers note that; “Treatment also induced post-translational changes in a variety of proteins such as CREB, PRAS40, AMPKa2 and several STATs indicating increased lipid metabolism and, possibly, mitochondrial activity. These results are supported by in vivo data from zebrafish and obese mice indicating that these cannabinoids are able to increase yolk lipid mobilization and inhibit the development of hepatosteatosis respectively.”

The study concludes; “Our results suggest that THCV and CBD might be used as new therapeutic agents for the pharmacological treatment of obesity- and metabolic syndrome-related NAFLD/hepatosteatosis.”

The study, conducted by researchers in Italy and the U.K, can be found by clicking here.

– TheJointBlog

4 thoughts on “Cannabis May Prevent and Treat Non-Alcohol Related Fatty Liver Disease”

  1. Don Kiernan. I too am in Florida. FT LAUDERDALE
    I might have found a way to get around present laws
    jenks vs state fl…..might also have doctors willing to approve.
    Charlene Wynant if you need more info contact thur Facebook

    Where are you in Florida?

  2. My opinion is people are dying every day and the natural medicine in cannabis is still illegal in the United States! I live in Florida and we have 57% of Floridians who favor a THC medical marijuana law. Fortunately we will pass it in 2016 but how many more will die before we can have our medicine of choice! I have hepatosteatosis and my physician does not approve of any cannabis treatments! I have to find another doctor!

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