Cannabis May Be A Gastroprotectant, Says New Study

A new study conducted by researchers at the Department of Pharmacology and Pharmacotherapy at Semmelweis University in Hungary, and published by the United States Natusnlmional Library of Medicine, has found promising evidence to suggest that cannabis may be a gastroprotectant.

According to the study; “Stimulation of central angiotensin AT1 receptors via activation of cannabinoid CB1 receptors [something which cannabis does naturally] induces gastroprotection in a DAGL-dependent and vagus-mediated mechanism.”

Here is the entire abstract from the study;

The aim of the present study was to analyze whether angiotensin II via the endocannabinoid system can induce gastric mucosal protection, since transactivation of cannabinoid CB1 receptors by angiotensin AT1 receptor in CHO cells was described. Experimental ulcer was induced by acidified ethanol given orally in male Wistar rats, CB1(+/+) wild type and CB1(-/-) knock out mice. The compounds were administered intracerebroventricularly. It was found, that 1./ Angiotensin II inhibited the ethanol-induced gastric lesions (11.9-191 pmol); the effect of angiotensin II (191 pmol) was inhibited by the CB1 receptor inverse agonist AM 251 (1.8 nmol) and the inhibitor of diacylglycerol lipase (DAGL), tetrahydrolipstatin (0.2 nmol). 2./ Angiotensin II exerted gastroprotection in wild type, but not in CB1(-/-) mice. 3./ The gastroprotective effect of angiotensin II (191 pmol) was reduced by atropine (1 mg/kg i.v.) and bilateral cervical vagotomy. In conclusion, stimulation of central angiotensin AT1 receptors via activation of cannabinoid CB1 receptors induces gastroprotection in a DAGL-dependent and vagus-mediated mechanism.


About Anthony Martinelli

Anthony, co-founder and Editor-in-Chief of TheJointBlog, has worked closely with numerous elected officials who support cannabis law reform, including as the former Campaign Manager for Washington State Representative Dave Upthegrove. He has also been published by multiple media outlets, including the Seattle Times. He can be reached at TheJointBlog@TheJointBlog.com.

1 comment

  1. Drew Bright

    Gastroprotectant, Neuroprotectant, AntiInflammatory, AntiTumoral …. do we have enough research to remove this healing plant from the CSA yet? We thought that change was imminent at the end of the 1970’s with the downfall of lying TrickyDick (who instituted the DEA/CSA conspiracy)…wha happened?! Here we are piecemealy begging for our rights to a non-toxic plant state-by-state? When with a penstroke the POTUS and Eric Holder could begin to undo the damage done by decades of deceitful machinations…HR 499 in the US House, NOW; get Your Congressman to Co-Sponsor this historic challenge to Federal Imperialism!

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