Cannabidiol May Treat Acne, Finds Study

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Cannabidiol May Treat Acne, Finds Study

A study published recently in the Journal of Clinical Investigation and the National Institute of Health has found that thecannabisleaf cannabis compound cannabidiol, often referred to simply as CBD, may provide a potential treatment for acne.

For the study, researchers used cannabidiol derived from cannabis on human sebaceous gland function, and determined that CBD behaves as a highly effective sebostatic agent.

“Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels”, claims researchers.

They continue; “Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling.”

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The study concludes; “Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.”

The research can be found on the National Library of Medicine’s website by clicking here.



  • Martin Rivera
    August 30, 2014

    So Cannibus aka weed lol could potentially help clear acne wow too bad its not legal in jersey thx for the post im going to look into it

  • Belle
    September 4, 2014

    That is really great! Wouldn’t it be interesting to see actual human trials?

  • isabel marshal
    February 26, 2015

    very nice blog !!

  • Lacy
    March 2, 2015

    This is quite interesting. The study has brought an insight of a product that few thought could bring a solution to acne. Now this is great news!

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