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New Study: Cannabinoid Deficiency Worsens Kidney Disease

A new study published in this month’s issue of the journal Kidney International, and published online by the U.S. National Institute of Healthkidney, has found that cannabinoid deficiency worsens diabetic nephropathy, a type of kidney disease, indicating that cannabinoid therapy may provide a treatment.

“A functionally active endocannabinoid system is present within the kidney”, begins the study’s abstract. “The¬†cannabinoid¬†receptor type 2 (CB2) is expressed by both inflammatory cells and podocytes, and its activation has beneficial effects in experimental diabetic nephropathy.” It continues; “To further explore the role of CB2 in diabetic nephropathy, we studied renal functional and structural abnormalities in streptozotocin-induced diabetic CB2 knockout mice.”

After conducting the studies, researchers found that; “Absence of CB2 [cannabinoid receptor type 2] on resident glomerular cells had a major role in worsening diabetic nephropathy, both functional and structural abnormalities, likely by enhanced MCP-1 and CB1 signaling.”

They conclude; “Thus, CB2 deletion worsens diabetic nephropathy, independent of bone marrow-derived cells.”

The study can be found by clicking here.

TheJointBlog

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About Anthony Martinelli

Anthony, co-founder and Editor-in-Chief of TheJointBlog, has worked closely with numerous elected officials who support cannabis law reform, including as the former Campaign Manager for Washington State Representative Dave Upthegrove. He has also been published by multiple media outlets, including the Seattle Times. He can be reached at TheJointBlog@TheJointBlog.com.

3 comments

  1. Bonnie

    So cannabis is supposed to help my stage 3 kidney disease ?

  2. Jeff

    Cannabis/Hemp is good for your health!

    The sicence of Cannabis,:
    http://youtu.be/5Q-31OE84u4

    Please share this info.

  3. Laura Reynolds

    Interested in hearing more about the benefits of cannabis and hemp, especially in philanthropy.

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