A compound meant to mimic the effects of natural cannabinoids was found to reverse the short and long-term deficits caused by repeated social defeat in a new study published by the journal Neuropsychopharmacology.
Psychosocial stress contributes to the development of psychiatric disorders. Repeated social defeat (RSD) is a murine stressor that causes a release of inflammatory monocytes into circulation. Moreover, RSD-induced anxiety-like behavior is dependent on the recruitment of these monocytes to the brain.
With this in mind, it’s important to note that “Activation of the endocannabinoid (ECB) system [done naturally through the consumtion of cannabinoids] may modulate both neuroendocrine and inflammatory responses mediated by stress”, states the study’s researchers. “Therefore, we hypothesized that a cannabinoid receptor agonist would attenuate RSD-induced inflammation, anxiety, and stress sensitization.”