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Study: THC Reduces Methamphetamine-Induced Brain Damage

A new study published in this month’s issue of the journal PLoS ONE, and published online by the National Institute of Health, has found that THC (Δ9-tetrahydrocannabinol) cancannabisthc reduce and even prevent brain damage caused by methamphetamine intake.

According to the study, titled Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity, “Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microglia stimulation, and induces hyperthermia and anorectic effects.” 

It continues; “Preclinical studies have shown that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthetic cannabinoid CB1 and CB2 receptor agonists exert neuroprotective effects on different models of cerebral damage. Here, we investigated the neuroprotective effect of Δ9-THC on METH-induced neurotoxicity by examining its ability to reduce astrocyte activation and nNOS overexpression in selected brain areas.”

Using rat models, researchers discovered that; “Our results indicate that Δ9-THC reduces METH-induced brain damage via inhibition of nNOS expression and astrocyte activation through CB1-dependent and independent mechanisms, respectively.”

The full study can be found by clicking here.

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About Anthony Martinelli

Anthony, co-founder and Editor-in-Chief of TheJointBlog, has worked closely with numerous elected officials who support cannabis law reform, including as the former Campaign Manager for Washington State Representative Dave Upthegrove. He has also been published by multiple media outlets, including the Seattle Times. He can be reached at TheJointBlog@TheJointBlog.com.

3 comments

  1. j

    I believe it.i felt i had brain damage from heavy meth use. the pain in my head lasted for a year until i pickedup smoking lettuce again. then the pain got less each day. true story. i oweeee that plant my life.

  2. Daniel Camerino

    Forget what you think you know about medical marijuana, you owe it to yourself to read up on the cutting edge research.
    http://www.encod.org/info/700-MEDICINAL-USES-OF-CANNABIS.html
    ^^^ 700 uses of Medical Marijuana | Sorted by Disease | ADD – Wilson’s
    also. FREE ! FREE! FREE! E-book – The Emperor Wears No Clothes.
    This is the book that started the cannabis hemp revolution. More than 600,000 copies have been sold to date. Jack wanted this information to be available to everyone, so he published the text of the book here on the internet for free.
    http://www.jackherer.com/thebook/
    http://www.cannabisinternational.org/

  3. Julia

    A fortunate Tip of the Ice Berg benefit of this God Given, Natural Medicine. About time people are Free to find and utilize what is Good for our bodies, rather than what is touted as safe..but actually toxic.

    We Live in a “Free” country…I absolutely Believe in the right to choose what is best to treat My Body!

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